Shelterins, a genetic crossroad in CLL

Intronic microRNAs: a crossroad in gene regulation.

Most human genes transcribed by RNA Pol II (polymerase II) contain short exons separated by long tracts of non-coding intronic sequences. In addition to their role in generating proteomic diversity through the process of alternative splicing, intronic sequences host many ncRNAs (non-coding RNAs), involved in various gene regulation processes. miRNAs (microRNAs) are short ncRNAs that mediate eit...

Paxillin: a crossroad in pathological cell migration

Paxilllin is a multifunctional and multidomain focal adhesion adapter protein which serves an important scaffolding role at focal adhesions by recruiting structural and signaling molecules involved in cell movement and migration, when phosphorylated on specific Tyr and Ser residues. Upon integrin engagement with extracellular matrix, paxillin is phosphorylated at Tyr31, Tyr118, Ser188, and Ser1...

Mathematical Proofs at a Crossroad?

For more than 2000 years, from Pythagoras and Euclid to Hilbert and Bourbaki, mathematical proofs were essentially based on axiomatic-deductive reasoning. In the last decades, the increasing length and complexity of many mathematical proofs led to the expansion of some empirical, experimental, psychological and social aspects, yesterday only marginal, but now changing radically the very essence...

Arthritis clinical trials at a crossroad.

CLL: a supplementary question?

In this issue of Blood, Shanafelt and colleagues provide the first evidence that vitamin D deficiency is a risk factor for disease progression in chronic lymphocytic leukemia (CLL). Their findings imply that dietary vitamin D supplementation could potentially modify the natural history of this incurable disease.